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As depicted in Figure 1, dipeptidylpeptidase-4 (DPP-4) is an ubiquitously expressed transmembrane protein that removes N-terminal dipeptides from various substrate hormones, chemokines, neuropeptides and growth factors

The theory holds that DSIP-enhanced deep sleep creates an optimal environment for GH release, while the secretagogues provide additional stimulation of GH production

Accessed 08 Nov 2024

To validate the mitochondrial localization of these proteins, they targeted four functionally uncharacterized candidates to the mitochondria and confirmed that three of them are indeed essential mitochondrial proteins