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A positive effect on cardiovascular outcomes is achieved through several mechanisms (2)

Faster weight reduction creates more dramatic hormonal shifts that can accelerate lean tissue breakdown alongside fat loss

Written by: Clara Hanson-Smith Reviewed by: Sunny Dhain MPharmRS PgDip IndP Date reviewed: 27/12/2023 Semaglutide is a synthetic analogue of the human glucagon-like peptide-1 (GLP-1)

In addition, orlistat's potential to cause liver damage and its association with severe liver outcomes, such as gallstone formation, obstructive jaundice, and acute liver failure, have been documented [68, 70]

In the same year, danuglipron, another small molecule oral GLP-1R agonist, also underwent phase two clinical trials