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The culture medium was removed, and the cells were incubated with serum-free DMEM containing 10 M DCFH-DA at 37 C for 20 min

To prevent or manage these side effects, healthcare professionals recommend a gradual increase in dosage and eating slowly

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Unlike natural -MSH, which activates MC4R through both the Gs and Gq protein signaling pathways, setmelanotide's cyclic structure biases it strongly toward Gq/11 signaling

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