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Therefore, CD44 serves as a signaling hub that integrates tumor microenvironmental signals and transmits these signals to signaling pathways involved in tumor progression, including EMT, angiogenesis, cell cycle regulation, and other oncogenic processes

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Why it works: The augmented fifth of the Gaug chord (D#) feels highly unresolved and naturally pulls upwards by a half-step to the note E, which is the third of the C Major tonic chord

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