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Firstly, some people believe that cerebral insulin resistance in patients with AD may not be insulin resistance in the true sense of the word but may instead arise from dysfunctional insulin transport across the BBB and that this transport defect may be caused by abnormal BBB function indirectly resulting from peripheral insulin resistance (Qian et al., 2024)

I would encourage patients to speak to their practice if they have concerns about their B12 treatment

For a broader comparison, the IV therapy vs oral supplements guide covers the full picture

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Most research protocols favor a strategy of smaller, more frequent doses (micro-dosing) during the initial loading phase