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GHK-Cu binds to extracellular matrix proteins (collagen, fibronectin, heparan sulfate proteoglycans) and copper-dependent enzymes like lysyl oxidase

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1 Introduction Neurodegenerative diseases (NDDs) comprise a heterogeneous group of disorders characterized by the progressive loss of neurons or myelin in the brain and spinal cord, including Alzheimers disease (AD), Parkinsons disease (PD), multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), and Huntingtons disease (HD) (Wilson et al., 2023)

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Available literature describes its association with signaling pathways involved in angiogenic regulation, including modulation of vascular endothelial growth factorrelated processes