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Just like cyanocobalamin, it has to be reduced from state +3 to +1 before it can become either methyl B12 or adenosyl B12

We also want to see if other GLP-1 drugs can provide similar relief, possibly with fewer gastrointestinal side effects, Braca noted

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Constipation from GLP-1 Medications: Functional Medicine Solutions for Relief GLP-1 receptor agonists such as semaglutide (Wegovy, Ozempic) and tirzepatide (Mounjaro, Zepbound) are transforming the treatment of obesity, insulin resistance, and type 2 diabetes

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