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Most of the work has been conducted with human primary dermal fibroblasts in which the effects of the endogenous peptide MSH were tested

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Currently, commercial products containing IGF-1 exist for transdermal application using a dermaroller, usually in combination with other growth factors such as bFGF (basic fibroblast growth factor) and VEGF (vascular endothelial growth factor), copper peptide, hyaluronic acid, coenzyme Q, vitamins B3, B6, and B5, and amino acids (arginine and lysine)

It is part of a complex "antioxidant network" in the body

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