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Iron accumulation may affect long-term cognitive dysfunction from three pathways: local injury, iron deposition induces tau phosphorylation, the formation of neurofibrillary tangles

Anyone of myocardial infarction, ischemic stroke, peripheral arterial disease, or coronary arterial disease

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Evidence supporting their therapeutic application in specific clinical populations such as individuals with metabolic syndrome or type 2 diabetes is considered separately and interpreted with caution

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