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Allosteric effects in the marginally stable von Hippel-Lindau tumor suppressor protein and allostery-based rescue mutant design

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Research published in Biochemical Pharmacology demonstrates that systemic administration of 5-Amino-1MQ to diet-induced obese mice produced approximately 5.1% body weight loss and 35% reduction in white adipose tissue mass over 11 days of treatment, without affecting total food intake

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