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Metformin inhibits the production of reactive oxygen species from NADH: ubiquinone oxidoreductase to limit induction of interleukin-1 (IL-1) and boosts interleukin-10 (IL-10) in lipopolysaccharide (LPS)-activated macrophages

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With regard to fibrosis, collagen deposition was largely unaffected by the treatments, except interestingly, the HGF-neutralising antibody + c-MET inhibitor (Hi + Ci)-treated tumours, which showed a significant decrease in collagen content when compared with those treated with gemcitabine alone

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Weight maintenance after stopping depends on lifestyle habits established during treatment