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While PAP does lead to greater reductions in AHI and higher rates of complete treatment response when compared to MADs, patients are generally able to better tolerate MADs compared to PAP, with higher patient-reported compliance [36]

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(2010) utilized IGF-1 and its analogs to investigate the relative contributions of PI3K/Akt versus MAPK/ERK signaling in IGF-1R-mediated cellular responses, demonstrating context-dependent pathway utilization across different cell types

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