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You could argue that GLP-1 MoA is somewhat derisked so you are not looking at at 90% risk of not making it to market (not knowing anything of the specific target in question here)

*From randomization to last contact with trial site, regardless of treatment discontinuation or rescue intervention

The criterion exists because in clinical experience the predictable failure mode for peptide therapy is prescribing the second-best peptide for a patient whose presentation pointed to a different first choice

This is not a binary debate between safety and access but a challenge to achieve both through thoughtful policy, responsible compounding, and equitable healthcare reform

Dihexa activates the hepatocyte growth factor receptor c-Met in hippocampal neurons, triggering PI3K/Akt and MAPK/ERK signaling cascades that increase synaptogenesis, dendritic spine density, and NMDA receptor expression