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Both Setria and SOD have strong safety profiles in clinical studies

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Abbreviations DKD: Diabetic kidney disease GPx: Glutathione Peroxidase HFD: High-fat diet MET: Metformin Nf-B: Nuclear factor kappa B Nrf2: Nuclear factor erythroid-2 ROS: Reactive oxygen species T2DM: Type 2 diabetes mellitus References Adelakun SA, Akomaye AJ, Omotoso OD, Arowosegbe OA (2024) Anti-hepatopathy and anti-nephropathy activities of Taraxacum officinale in a rat model of Streptozotocin diabetes-induced hepatorenal toxicity and dyslipidemia via attenuation of oxidative stress, inflammation, apoptosis, electrolyte imbalances, and mitochondrial dysfunction

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As CNS GSH concentrations are thought to be reduced in PD, a relatively large voxel size was selected in order to maximize signal to noise