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Boltze, J., Modo, M

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On March 31st, 2022, the FDA denied the NPA petition as well as another one submitted by the Council for Responsible Nutrition (CRN)

156,157 This process leads to the detachment of tau protein from microtubules, followed by conformational changes and mislocalization, accumulation of tau oligomers, paired helical filaments (PHFs), and NFTs within the cell body and dendrites