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Paglia DE, Valentine WN

Of the 48 inter-molecular NOE restraints, only 2 NOEs could be assigned unambiguously and correspond to contacts between p53-Trp53 HE# - FOXO4-Leu160 HD# and p53-Trp53 HD#FOXO4-Leu109 HD# (Supplementary Note 1)

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Beyond its role in actin dynamics, it also moonlights as a transcriptional modulator of nitric oxide synthase pathways, angiogenesis, proliferation, and immuno-inflammation: it attenuates NF-B and TLR , reduces cytokines such as TNF- and IL-6 , and activates PI3K/Akt/eNOS , Notch , and Ang1/Tie2