Thorner MO, Rochiccioli P, Colle M
SFN is a sulfur-containing isothiocyanate that is mainly derived from the family of Brassicaceae flowering plants, also known as Cruciferae ( Brassica oleracea , which includes some widespread edible vegetables such as broccoli, cabbage, brussels sprouts, cauliflower, and kale ( Figure 1B ) ( Figure 1 The natural production of SFN occurs principally via a chemical reaction between glucoraphanin and plant thioglucosidases (myrosinases) after tissue damage or, if myrosinases were denatured via cooking before freezing, the reaction will occur between glucoraphanin and microbial thioglucosidases in the colon ( Figure 1C demonstrates the mechanism of the hydrolysis of glucoraphanin by myrosinase and the subsequent production of its biologically active metabolite, SFN
IV delivery bypasses the digestive tracts natural absorption limits entirely
Preclinical studies in rodents show it enhances synaptic connectivity and spatial memory retention with reported potency millions of times greater than BDNF
Wybr midzy nimi zaley od projektowanego ukadu eksperymentalnego czy badacz potrzebuje jednego szlaku, czy obu jednoczenie
