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To test the statistical significance of the findings from the t-SNE analysis, the expression of activation markers following in vitro stimulation of PBMCs with treated SIHUMIx, collected at run days 7, 10, 15 and 23, was quantified by flow cytometry for all individual blood donors and analyzed using a conventional, manual gating strategy ( Supplementary Figure 2 )

We, like many other observers in the field ( Funding This work was funded by the Canadian Institute of Health Research (Foundation Grant 375104 to LP), Bucke Family Fund (LP and PS) and the Academic Medical Organization of South Western Ontario (LP), the National Natural Science Foundation of China (No

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