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It stimulates the skin system,restoring skin to its normal physiological state

Exp Ther Med 21(6):19 Tokuhiro S, Yamada R, Chang X, Suzuki A, Kochi Y, Sawada T, Suzuki M, Nagasaki M, Ohtsuki M, Ono M (2003) An intronic SNP in a RUNX1 binding site of SLC22A4, encoding an organic cation transporter, is associated with rheumatoid arthritis

Human transporters, PEPT1/2, facilitate melatonin transportation into mitochondria of cancer cells: an implication of the therapeutic potential

It can be directly absorbed by cells across the skin barrier, because of its small molecular weight (307 Daltons), and directly inhibit the activity of tyrosinase