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The SELECT cardiovascular outcomes trial (Lincoff et al., 2023, New England Journal of Medicine) enrolled 17,604 adults with obesity and established cardiovascular disease no diabetes, and demonstrated a 20% reduction in major adverse cardiovascular events (MACE) with 2.4mg semaglutide versus placebo

Semaglutide comes as a traditional shot, typically injected once a week subcutaneously (under the skin) in the upper arm, stomach, or thigh

Not without trying the management protocol first

Be patient with yourself and celebrate progress along the way

KBP-066A, a long-acting dual amylin and calcitonin receptor agonist, induces weight loss and improves glycemic control in obese and diabetic rats