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Glutathione peroxidase 1 (GPX1) is one of the most abundant members of the GPXs family that protects cell from oxidative damage and maintains the balance of intracellular redox systems (Sharma et al., 2021a), GPX1 is a gatekeeper restraining the oncogenic power of mitochondrial ROS generated by superoxide dismutase 2 (SOD2) (Wen et al., 2014)

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PARP-1 inhibitor, DPQ, attenuates LPS-induced acute lung injury through inhibiting NF-B-mediated inflammatory response