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14 Although the SNpc and SNpr are anatomically in proximity to each other, their functional roles are largely disparate

NRF2, however, is no longer ubiquitinated and degraded in response to elevated oxidative stress or mutations in KEAP1, CUL3, or NRF2

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[7] They are generally well-tolerated, with common adverse effects including headache, facial flushing, nasal congestion, and dyspepsia