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While human data is more limited, case reports from 2025-2026 suggest similar benefits in clinical practice, with women reporting improved mobility and reduced pain during menstruation

The pattern is that both are GI-forward drugs, but retatrutides glucagon activity adds a cardiovascular consideration (heart rate) that cagrilintides amylin mechanism does not, and the same potency that produces retatrutides larger weight loss is associated, in indirect analyses, with a heavier adverse-event load

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