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In October 2024, The US FDA Breakthrough Therapy designation is for the treatment of adults with non-cirrhotic metabolic dysfunction-associated steatohepatitis (MASH) and moderate or advanced fibrosis, based on survodutides groundbreaking results from Phase II study

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(e) Heatmap showing Glp-1r and Gipr mean gene expression in hypothalamic non-neuronal cell types

Any discussion of pineal-gland lineage, circadian biology, or aging-associated pathways is presented solely as research context and does not imply human-use benefits

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