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Progress monitoring at weeks 4, 8, and 12 with protocol adjustment

In rectal cancer chemoradiotherapy and metastatic renal cell carcinoma combinations, CRLX101 has produced signals consistent with vascular normalization and radiosensitization, although randomized trials have so far shown mixed results for hard outcomes such as progression-free survival [91, 92]

Gonzalez-Freire M, Diaz-Ruiz A, Hauser D, Martinez-Romero J, Ferrucci L, Bernier M, de Cabo R (2020) The road ahead for health and lifespan interventions

doi: 10.1007/s00213-024-06735-1

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