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Approximately 11.9-fold increase in endogenous MOTS-c levels have been found in skeletal muscle following exercise (compared to pre-exercise values), and this increase can remain for 4 hours following exercise (19)

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"Superoxide radical and iron modulate aconitase activity in mammalian cells"

In the 6-OHDA-induced PD model, iron promotes LRRK2 activation via phosphorylation at S935 and S1292 sites