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Murine models of SLE demonstrate abnormally high levels of NO compared with normal mice, whereas systemic blockade of NO production reduces disease activity

Common injection sites in research studies include the abdomen, thigh, or upper arm regions

However, the mean baseline of 4.2 for ice pick scars remained unaffected throughout the treatment period

van Ophoven A, Pokupic S, Heinecke A et al: A prospective, randomized, placebo controlled, double-blind study of amitriptyline for the treatment of interstitial cystitis