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It is important to consult with a healthcare provider before considering vitamin injections to ensure proper dosing and to identify any potential underlying health issues

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Severe B3 deficiency (pellagra) causes gastrointestinal, dermatological, and neuropsychiatric symptoms including depression, insomnia, and hallucinations that can either mimic or intensify withdrawal symptoms

Slow dose escalation is the primary tool for managing GI discomfort

However, some research suggests that early morning might be the optimal time for taking vitamin B12 because water-soluble vitamins must be taken on an empty stomach