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Mutations in the genes encoding estrogen hormone, ESR1 , are associated with acquired resistance (intrinsic or extrinsic) to endocrine therapies (59)

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Showed transient elevations in serum concentrations of organochlorine pesticides and polychlorinated biphenyls during the first 612 months post-surgery

Importantly, IDH-1/2 mutations pose an important anti-cancer strategy for hard-to-treat cancer types, these mutations occurring in ~ 7080% of lower-grade gliomas and the majority of secondary glioblastomas and in up to 20% of patients with AML [261, 262]

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