Crucially, Nrf2 knockout models exhibit diminished SLC7A11 and HO-1 protein expression, which potentiates ferroptotic susceptibility ( 6.4 Autophagy pathway Beclin-1, a core autophagy-related protein, drives autophagosome formation, while UNC-51 like kinase 1 (ULK1) coordinates autophagic initiation through its kinase complex (Kim et al., 2011)
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A preferred method of accelerating this dissolution process is to preblend the drug and polymer by cryo-milling
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