what happens when you stop taking glp-1 medication Should Suddenly GLP-1s? Our Experts Weigh In What Happens When You Stop

However, the physiological half-life of GLP-1 in circulation is very short (less than 2 min), which can be attributed to both rapid proteolytic cleavage of the amide bond of alanine at position 8 (Ala8) in the N-terminus by ubiquitous dipeptidyl peptidase IV (DPP-IV), which results in the removal of the two N-terminal amino acids leading to the formation of a truncated inactive form 10,11 and clearance by the kidney as well

1 Depending on the specific molecules half-life, GLP-1 medications can also have a short-release or extended-release action, determining how long their effects last in the body

They were also asked about GLP-RA use, including the specific drug, reasons for use, duration, side effects, and expected period of future use

The role of beta cell glucagon-like peptide-1 signaling in glucose regulation and response to diabetes drugs

Journal of Neuroscience Research