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Building on these findings, we combined functional and phenotypic cell death assessments, transcriptomic data, and syngeneic tumor models in murine melanoma and colorectal cancer cell lines to demonstrate that lipophilic statins uniformly promote ferroptosis by depleting GPX4 and that statin-induced ferroptosis augments antitumor immune responses following -PD1 checkpoint blockade

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Label with peptide name, concentration, reconstitution date, and lot number

Lee CA, Lillibridge JH, Nelson SD, Slattery JT: Effects of caffeine and theophylline on acetaminophen pharmacokinetics: P450 inhibition and activation