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GLP-1 receptor agonists should only be continued if there is an adequate response, defined as a reduction of at least 11 mmol/mol (1.0%) in HbA1c and a weight loss of at least 3% of initial body weight at six months

Senolytic FOXO4-DRI can inhibit FOXO4 binding by disrupting the p53-FOXO4 interaction and selectively cause apoptosis via p53 nuclear exclusion in senescent cells and aging mouse models, which may be a promising approach for preventing senescence 11

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The clinical outcome on right side was considered as very good in 5 (56%) cases of patients, good in 3 (33%) patients, excellent in one (11%) patient, while on left side the improvement was poor in 8 (78%) patient and good in one (22%) patient (Fig