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Several preclinical studies have demonstrated that exposure to vitamin D can modulate the activity of the Klotho protein

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Lets explore how B-complex vitamins aid in detoxification: Detoxifying Effects of B-Complex Vitamins on the Liver: B-complex vitamins, such as B2 (riboflavin), B3 (niacin), B5 (pantothenic acid), and B6 (pyridoxine), play important roles in liver function and detoxification processes

Studies found that melatonin administration can reverse nervous system harmful effects of Mn through inhibition of Keap1 and consequently, activation of the Nrf2/ARE signaling pathway (NaveenKumar et al., 2019)