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This dual-action mechanism explains why it is highly sought after as a solution for metabolic health challenges

doi: 10.1128/JVI.76.10.5260-5265.2002 143 GallagherGRBrehmMAFinbergRWBartonBAShultzLDGreinerDLet al

Besides being the sole antioxidant enzyme able to repair lipid peroxides, GPX4 is a moonlighting protein that also regulate eicosanoid biosynthesis ( Hydroperoxides relevant to inflammation are those formed from arachidonic acid (AA) by stereoselective lipoxygenases

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Celastrol protects mouse retinas from bright light-induced degeneration through inhibition of oxidative stress and inflammation