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In type 2 diabetes [161] and sickle cell disease [162], The NLRP3 inflammasome has been reported to drive chronic low-grade inflammation by recognizing cytoplasmic mtDNA or mitochondrial ROS, recruiting the ASC adaptor protein and pro-caspase-1, and mediating IL-1/IL-18 maturation and cell death

Nutrients 2020;12:963

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NEVER use bacteriostatic saline in neonates or infants due to risk of benzyl alcohol toxicity (gasping syndrome)