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The GIPR missense variant, rs1800437, has been associated with a large number of traits in the public domain, including BMI and body mass phenotypes, T2D, blood glucose and a number of metabolic or haematologic traits including blood pressure, reticulocyte and/or erythrocyte volume and urinary calculus (Supplementary Table 18)

466 One study proposed a novel mechanism wherein postprandial GLP-1 release, under normal physiological conditions, inhibits the activity of chemosensory cells in the carotid body, thereby counteracting sympathetic excitability mediated by elevated blood glucose or insulin levels