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These fragments stimulate inflamed synovium cells (synoviocytes, macrophages, lymphocytes) to secrete cytokines, chemokines, and lipid mediators, as well as more ROS and MMPs, which can directly degrade the components of the cartilage matrix or dysregulate the metabolism of chondrocytes, leading to an imbalance between cartilage matrix degradation and synthesis

2025 Feb 5;14(1):18

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Detection of intracellular ROS through DCFH-DA probe Based on the experimental grouping described above, the production rate of ROS was detected using the DCFH-DA probe