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BDNF exerts multiple biological actions through TrkB receptors (13,28)

Nagahara, N., Okazaki, T

The second cause of leptin resistance is impaired leptin signal transduction in neurons, including SOCS3, PTP1B

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Uncontrolled muscle biopsy studies enrolling patients with T2DM show that 12 weeks of pioglitazone 30 mg once daily improved skeletal muscle mitochondrial respiration measured by high-resolution respirometry of muscle biopsies, whereas 12 weeks of rosiglitazone 4 mg once daily worsened mitochondrial respiration [123]