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( E and F ) Plasma concentrations of GIP ( E ) and GLP-1 ( F ) in fasted Tmprss2 / and WT mice

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The ensuing negative feedback loop may involve not only EECs but also Paneth cells and intestinal intraepithelial lymphocytes, as these cells have been reported to express the receptor for GLP-1 (namely GLP-1R), and loss of GLP-1R increases the severity of DSS-induced intestinal injury8, 9