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It is well known that TGF- prevents the sensitized T cells migration into the CNS, and protects against EAE and MS, while IL-12 may play a major role in EAE development through the induction of both Th1 and Th17 cells differentiation, and both may play a complementary role in the EAE disease pathogenesis (Fletcher et al., 2010)

Within this mechanistic framework, natural compounds with antioxidant and anti-inflammatory properties, including vitamins C and E, glutathione precursors, CoQ10, L-carnosine, polyphenols including quercetin, resveratrol, and curcumin, and saffron metabolites like crocin and safranal show biological plausibility and preliminary efficacy on biochemical and behavioral endpoints

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Ideally, a sufficiently large study is needed to better quantify these risk." There you have it