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Now, lets address the key question: Which semaglutide has the least side effects

Klausen MK, Jensen ME, Mller M, et al

A critical reassessment of historical failures reveals that many appetite-related peptide programs were abandoned not because their biology was flawed, but because early development conflated dose-dependent adverse effects or behavioral complexity with intrinsic target unsuitability (Lau et al., 2015

These salt forms of GLP-1s have not been proven safe and effective in humans or approved by the FDA, Basina noted, adding that effectiveness can be different due to the salt form differences. Additives To differentiate their products from the FDA-approved GLP-1s, many compounders add extra ingredients most commonly vitamin B12, but also B6, niacinamide, glycine or carnitine that have no proven benefit for weight loss or diabetes management

DISCLOSURES Cindy Wassef, Radhika Shah, Mahin Alamgir, Samantha Ouellette, and Giulia Frias have no conflicts of interest to disclose