Although previous studies have largely assigned depressive symptoms to the three monoamine neurotransmitters (dopamine, norepinephrine, or serotonin), we describe a specific peripheral glutamatergic dysfunction (decreased GDH activity in K2 relatively control) that accompanies distinct clinical DE phenotypes with a predominance of parkinsonian neurological symptoms
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These unknowns represent the gap that formal clinical trials would address
Ferreira SC, Bruns RE, Ferreira HS, Matos GD, David JM, Brandao GC, da Silva EP, Portugal LA, Dos Reis PS, Souza AS, Dos Santos WN (2007) Box-Behnken design: an alternative for the optimization of analytical methods