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Conditions that prevent use include a personal or family history of medullary thyroid carcinoma, Multiple Endocrine Neoplasia syndrome type 2, a history of severe pancreatitis, pregnancy, and active gallbladder disease

Your healthcare provider will help you find treatments that reduce how much AS symptoms interfere with your day-to-day routine

On April 1, 2026, the FDA approved Foundayo (orforglipron) from Eli Lillythe first oral small-molecule GLP-1 receptor agonist for chronic weight management

For readers comparing approved incretin options, Mounjaro and Type 2 Diabetes gives background on tirzepatide in clinical care