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PCS samples showed mixed or decreased abundance of key mitochondrial metabolic enzymes (PDHB, DLST, ACADM), suggesting persistent inefficiency in TCA flux and fatty acid oxidation

Contrave can be used (along with diet and exercise) as a long-term treatment for chronic weight management in adults with an initial body mass index (BMI) of: 30 kg/m2 or more (obese), or 27 kg/m2 or more (overweight) with at least one weight-related condition such as high blood pressure, diabetes, or high cholesterol Contrave has not been studied along with other weight-loss medications, including prescription medicines, over-the-counter drugs, or dietary supplements

any use outside a trial is unlicensed and not recommended

Submit a New Drug Application (NDA): Eli Lilly is expected to submit a New Drug Application (NDA) to the FDA for obesity if the Phase III program is successful

This, in turn, signals the body to produce and release more GH through somatotropic cells