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The C cell is a neuroendocrine cell with quasi-neuronal properties (uptake of biogenic amines and neuronal features when placed in tissue culture) combined with endocrine secretory peptide production analogous to adrenal chromaffin, pancreatic or gastrointestinal neuroendocrine, and certain pituitary cells

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Cofactor (biochemistry) A cofactor is a non-protein chemical compound or metallic ion that is required for an enzyme's role as a catalyst

J Med Chem 61:32183223

As a matter of fact, I get asked this question almost every day