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We report the cryo-EM structure of TGR demonstrating that these inhibitors bind at the doorstop pocket preventing the NADPH oxidation steps

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Our results showed that doxorubicin + , daunorubicin, and irinotecan + exhibited strong self-aggregation capabilities, which were enhanced to varying degrees by SO 4 2 , citrate 3 , copper gluconate, and SOS 8