Sugar alcohols (sorbitol, mannitol, xylitol) found in sugar-free gum, mints, and many diet products can cause gas, bloating, and diarrhea in some individuals
Analyses of the effects of FFA (NEFA) on macrophages in cell culture demonstrated that they can activate inflammatory signaling through the toll-like receptors (TLR), specifically TLR4
A total of 3286 patients had taken a GLP-1 RA and 1692 had taken an SGLT2i at some point in time
Elevance Health is reportedly buying home health company CareBridge in a $2.7 billion deal
KEY FINDINGS Average weight loss on treatment: 7.9 kg (all GLP-1s) 16.1 kg (newer GLP-1s like semaglutide/tirzepatide) Weight regained after stopping: 0.70.8 kg/month 8.39.6 kg regained in the first year Full return to baseline: 0.9 years (older GLP-1s) 1.7 years (newer GLP-1s) Bottom line: GLP-1s are effective, but without ongoing treatment or structured long-term care, the benefits fade quickly