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A review in the Archives of Physiology and Biochemistry examined the potential mechanisms of berberine in glucose metabolism, including pathways associated with GLP-1

13 Less common but important side effects include: Gallstones (rare) Kidney problems, especially in older adults who already have kidney disease Significant weight loss, which could be concerning for frail elderly people Special considerations for older adults: Stomach problems can lead to dehydration, which can be more serious in older adults

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doi: 10.1152/ajpregu.1999.276.5.R1541 25 SchloglHKabischSHorstmannALohmannGMullerKLepsienJet al