The current standard operating procedure by the European Center for the Validation of Alternative Methods (ECVAM) recommends the use of MTT reduction as parameter to make prediction on the skin irritancy of substances using EpiSkin TM test method, while IL-1 endpoint is regarded as a useful adjunct to MTT assay 48
7 Pathophysiology Both lymphocytic IBD and lymphocytic neoplasia are often recognized simultaneously in the same cat,40, 84 and numerous authors have suggested that lymphocytic IBD may be a precursor to intestinal lymphoid neoplasia.90, 125 If this is the case, then antigenic factors, such as bacterial population changes or food sensitivities, could be considered primary initiating factors for small cell lymphoma since they are potential underlying etiologies of IBDs
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